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Wednesday, August 12, 2020 | History

4 edition of Pathobiology of human germ cell neoplasia found in the catalog.

Pathobiology of human germ cell neoplasia

Pathobiology of human germ cell neoplasia

  • 266 Want to read
  • 40 Currently reading

Published by Springer-Verlag in Berlin, New York .
Written in English

    Subjects:
  • Germ cells -- Tumors -- Pathophysiology -- Congresses

  • Edition Notes

    StatementJ.W. Oosterhuis, H. Walt, I. Damjanov, eds.
    SeriesRecent results in cancer research ;, 123
    ContributionsOosterhuis, J. W., Walt, H. 1943-, Damjanov, Ivan.
    Classifications
    LC ClassificationsRC280.G4 P37 1991
    The Physical Object
    Paginationxii, 195 p. :
    Number of Pages195
    ID Numbers
    Open LibraryOL1535468M
    ISBN 10354053928X, 038753928X
    LC Control Number91013432

    The homolog has emerged as a gene with an enormously complex function that is distinct from that of. It encodes two distinct transcript isoforms that have a dramatic impact on replenishment of cutaneous epithelial stem cells and on ovarian germ cell survival. However, although these two fundamental roles of p63 attest to its powerful place in development, its other functions—specifically. Regardless of these differences, the availability of a heritable, highly penetrant model of germ cell neoplasia may provide valuable insight into the origins of human GCTs. It is noteworthy, for example, that exposure of the lamc1 cz61 line to either DMBA or MNNG resulted in enhanced germ cell tumorigenesis, indicating that the model could be.

    Intratubular germ cell neoplasia, unclassified is the precursor lesion of all invasive germ cell tumors with the possible exceptions of spermatocytic seminoma, pediatric yolk sac tumor, and pediatric teratoma. It is found in virtually all cases in which residual seminiferous tubules are identified around an invasive germ cell tumor.   In this Seminar, we focus on the most common testicular tumours that arise in post-pubescent adolescents and young adults and that arise from germ cell neoplasia in situ, previously termed carcinoma in situ, testicular intraepithelial neoplasia, or intratubular germ cell neoplasia unclassified. 4 These tumours are divided into morphologically homogeneous seminomas (roughly .

    This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and s: 2.   Introduction. The incidence of testicular germ cell tumors (TGCTs) has increased considerably during the last 50 years and is currently the most frequent malignancy in men aged 15 to 44 years in the Western developed evolve from the precursor intratubular germ cell neoplasia unspecified (also known as carcinoma in situ), which is hypothesized to originate in utero .


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Pathobiology of human germ cell neoplasia Download PDF EPUB FB2

Pathobiology of Human Germ Cell Neoplasia is a state-of-the-art compendium on a very recent branch of tumor biology. It offers an awareness and understanding of germ cell tumors: from the earliest stages to their va- rious differentiations.

Pathobiology of Human Germ Cell Neoplasia is a state-of-the-art compendium on a very recent branch of tumor biology. It offers an awareness and understanding of germ cell tumors: from the earliest stages to their va- rious differentiations.

Original data for this volume was supplied by experts in. Abstract. The term germ cell neoplasia is used today histogenetically to define a rather heterogeneous group of tumors whose origin and morphogenesis can be best explained by postulating that they all originate from germ cells.

Since most germ cells reside in the gonads, germ cell tumors are predominantly located in the testis and the ovary. However, morphologically identical tumors occur in Cited by: Overview.- Pathobiology of Human Germ Cell Neoplasia.- Cells of Origin.- Carcinoma in Situ of Pathobiology of human germ cell neoplasia book Testis: Possible Origin, Clinical Significance, and Diagnostic Methods.- Characterization of Precancerous and Neoplastic Human Testicular Germ Cells.- Cytogenetic Investigation of Gonadal Carcinomas in Situ in Syndromes of Abnormal Sexual.

Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : J.A. Ledermann. Pathobiology of Human Germ Cell Neoplasia is a state-of-the-art compendium on a very recent branch of tumor biology.

It offers an awareness and understanding of germ cell tumors: from the earliest. Abstract. Germ cell tumors (GCTs) are benign or malignant neoplasms, presumably derived from pluripotent or primordial germ cells.

During the development of the embryo, germ cells migrate from the yolk sac endoderm usually to the genital ridge in the retroperitoneum, where. Our investigations of i(12p) in human germ cell cancer provide further support for the diagnostic importance of this cytogenetic marker.

This review presents the molecular and cytogenetic studies from the Memorial Sloan-Kettering Cancer Center principally concerning chromosome 12 in primary and metastatic germ cell tumors and in established. Delozier-Blanchet CD, Walt H, Engel E, Vaugnat P () Cytogenetic studies of human testicular germ cell tumors.

Int J Androl 69–78 PubMed CrossRef Google Scholar Ewing J () Teratoma testis and its derivatives. Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease.

The work spans more than 48 different biological and medical fields, in five basic sections. Two microscopically distinguishable components (designated soft and firm) of a human testicular germ cell tumor with borderline histology between seminoma, embryonal carcinoma and yolk sac tumor, were maintained as xenografts in nude mice for over 20 passages.

Edith Hawkins, Stephen A Heifetz, Roger Giller, Barbara Cushing, The prepubertal testis (prenatal and postnatal): Its relationship to intratubular germ cell neoplasia: A combined pediatric oncology group and children's cancer study group, Human Pathology, /S.

Heterogeneity of human germ cell cancers: biology and clinical relevance. OPTIMAL PATIENT CARE Diagnosis -- Treatment -- Follow-up Pathobiology of germ cell tumors (AC(E) Germ cell neoplasia dependent on cell of origin KITLG-KIT DMRT1 OCT3/4-AP.

Intratubular germ cell neoplasia in situ initially grows beyond the basement membrane to eventually replace some or all of the testicular parenchyma. Because 50% of patients with testicular CIS will progress to a GCT, patients with this finding on testis biopsy (usually performed as part of an infertility evaluation) should undergo radical orchiectomy.

Germ cell tumors that occur in places other than the testicles and ovaries (extragonadal germ cell tumors) are very rare. Germ cell tumors tend to respond to treatment and many can be cured, even when diagnosed at a late stage. A germ-cell tumor (GCT) is a neoplasm derived from germ -cell tumors can be cancerous or cells normally occur inside the gonads (ovary and testis).GCTs that originate outside the gonads may be birth defects resulting from errors during development of the embryo.

Uwe M Galli, Marlies Sauter, Bernd Lecher, Simone Maurer, Hermann Herbst, Klaus Roemer, Nikolaus Mueller-Lantzsch, Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors, Oncogene, /, 24, 19, (), ().

4. Noninvasive germ cell neoplasia. In the recently published WHO Classification of Tumours of the Urinary System and Male Genital Organs, the term germ cell neoplasia in situ (GCNIS) has replaced the older terms intratubular germ cell neoplasia, unclassified and carcinoma in has been recognized as a common precursor lesion for most malignant testicular GCTs since ().

In situ stage of germ cell neoplasia; the common precursor of seminomas and nonseminomas GCNIS is seen in 80% - 95% of testes adjacent to germ cell tumor (GCT) (Arch Pathol Lab Med ;, Hum Pathol ;), in ~5% contralateral testis (Eur Urol ;) and nearly 50% of patients with extragonadal GCT (Lancet ;) 50% progress to GCT in 5 years.

Introduction: Germ Cell Tumors in General Epidemiology A number of different cell types can be found in the testis (germ cells, Sertoli cells, Leydig cells, mesenchymal cells, mesothelial cells, among others); thus, and despite being a relatively small organ, the testis may give rise to.

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): g (external link).The story of testicular ‘carcinoma in situ’/intratubular germ cell neoplasia is fascinating and serves as a paradigm for the concept of progression from incipient or preinvasive neoplasia to.